Aripiprazole and Hives: Can It Help Reduce Skin Irritation?

May, 27 2023

Introduction to Aripiprazole and Its Effects on the Skin

Aripiprazole is a medication that has gained popularity in recent years for its effectiveness in treating a variety of mental health disorders, such as bipolar disorder, schizophrenia, and depression. While the benefits of this medication are well-documented, it's important to consider the potential side effects that may come along with its use. One possible side effect that many people are curious about is whether or not aripiprazole can help reduce skin irritation, specifically hives. In this article, I'll be discussing the connection between aripiprazole and hives and whether or not this medication can help alleviate skin irritation.

Understanding Hives and Their Causes

Before diving into the relationship between aripiprazole and hives, it's important to first understand what hives are and what causes them. Hives, also known as urticaria, are raised, red, itchy welts on the skin that can vary in size and shape. They are often the result of an allergic reaction or an immune system response to a foreign substance. Some common triggers for hives include certain foods, medications, insect bites, and exposure to heat or cold.


For some individuals, hives can be a chronic issue, lasting for months or even years. In these cases, the exact cause of the hives may be difficult to pinpoint, and treatment can be more challenging. This is where aripiprazole may come into play as a potential treatment option for those suffering from chronic hives.

Aripiprazole's Mechanism of Action

Aripiprazole is an atypical antipsychotic medication that works by balancing the levels of certain neurotransmitters in the brain, such as dopamine and serotonin. This balance helps to stabilize mood and reduce symptoms associated with mental health disorders. However, the exact mechanism by which aripiprazole may affect skin irritation and hives is not entirely understood.


Some researchers believe that the anti-inflammatory properties of aripiprazole may play a role in reducing skin irritation. Additionally, aripiprazole has been shown to have antihistamine effects, which could potentially help alleviate hives by blocking the release of histamine, a substance that causes inflammation and itching in the skin.

Evidence Supporting Aripiprazole's Effect on Hives

There is limited evidence to support the notion that aripiprazole can help reduce skin irritation and hives. Some case reports have documented individuals with chronic hives who experienced significant improvement in their symptoms after starting aripiprazole treatment. However, these cases are anecdotal and do not provide definitive proof that aripiprazole is an effective treatment for hives.


More extensive research is needed to determine the true efficacy of aripiprazole in treating hives and skin irritation. Until then, it's important to approach this potential treatment option with caution and to consult with a healthcare professional before starting any new medication.

Side Effects of Aripiprazole to Consider

While aripiprazole may potentially help some individuals with hives, it's important to consider the potential side effects that may come along with its use. Common side effects of aripiprazole include weight gain, dizziness, drowsiness, and nausea. In some cases, aripiprazole may even cause skin irritation or allergic reactions, which could exacerbate hives rather than improve them.


If you're considering trying aripiprazole as a potential treatment for hives, it's essential to weigh the potential benefits and risks with your healthcare provider to determine if it's the right choice for you.

Alternative Treatments for Hives

If you're hesitant about trying aripiprazole for hives due to the potential side effects or lack of conclusive evidence, there are other treatment options available. Over-the-counter antihistamines, such as cetirizine or loratadine, can help alleviate itching and inflammation associated with hives. Prescription medications, such as corticosteroids or leukotriene inhibitors, may also be recommended for more severe cases of hives.


In addition to medications, lifestyle changes and home remedies can help manage hives. Avoiding known triggers, applying cool compresses to the affected areas, and using mild, fragrance-free skincare products can all help soothe irritated skin.

Consulting with a Healthcare Professional

Before starting any new medication for hives, including aripiprazole, it's important to consult with a healthcare professional. They can help determine the underlying cause of your hives, recommend appropriate treatment options, and monitor your progress throughout treatment. They can also help you weigh the potential risks and benefits of using aripiprazole for hives to make an informed decision about your care.

Conclusion: Aripiprazole and Hives

In conclusion, there is limited evidence to support the use of aripiprazole as a treatment for hives and skin irritation. While some case reports have documented positive results, more extensive research is needed to determine its true efficacy. If you're considering using aripiprazole to treat hives, it's crucial to consult with a healthcare professional to weigh the potential benefits and risks. There are alternative treatments available for hives, such as antihistamines and corticosteroids, that may be more appropriate for your specific needs.